Dbd blight new skin8/3/2023 It is well clarified that the biological functions of CAP involve ultra-violet radiation, reactive oxygen species, and reactive nitrogen species while exhibiting little damage to the normal cells or tissues ( 7). As an innovative non-invasive application, cold atmospheric plasma (CAP) has exhibited significant efficacy in treating skin diseases such as microbial infections, cutaneous wounds, cancers, and ncISDs ( 5, 6). However, these applications have still been challenged due to systemic side effects, the high recurrence rate of the disease, or the serious impact on daily life or working ( 4). Currently, the comprehensive treatments include systemic or topical medications or in combination with different phototherapies. The pathogenic factors of these skin disorders include microbial infections, excessive cytokines release, inflammatory cell infiltration, and aberrant cell proliferation or differentiation ( 1– 3). It is widely accepted that there are various kinds of skin diseases, including infectious diseases, cancers, wounds, and non-communicable inflammatory skin diseases (ncISDs). This review summarizes recent advances in CAP therapies for various skin diseases and implicates future strategies for increasing effectiveness or broadening clinical indications. With its generation of reactive oxygen species and reactive nitrogen species, CAP exhibits significant efficacies in inhibiting bacterial, viral, and fungal infections, facilitating wound healing, restraining the proliferation of cancers, and ameliorating psoriatic or vitiligous lesions. Cold atmospheric plasma (CAP), as an innovative and non-invasive therapeutic approach, has demonstrated its safe and effective functions in dermatology. The traditional therapies for skin diseases, such as oral or topical drugs, have still been unsatisfactory, partly due to systematic side effects and reappearance. The pathogenesis might include microbial infections, autoimmune responses, aberrant cellular proliferation or differentiation, and the overproduction of inflammatory factors. Skin diseases are mainly divided into infectious diseases, non-infectious inflammatory diseases, cancers, and wounds. 3School of Electrical Engineering, Xi’an Jiaotong University, Xi’an, China.2Center of Plasma Biomedicine, State Key Laboratory of Electrical Insulation and Power Equipment, Xi’an Jiaotong University, Xi’an, China.1Department of Dermatology, The Second Affiliated Hospital of Xi’an Jiaotong University, Xi’an, China.
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